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In the absence of a “magic bullet” for prevention or cure, attention is shifting to therapies that target pre-existing immune processes that mediate disease or that modulate pathogenic processes as the disease progresses. Here, as with antimicrobial therapy, the use of a PK/PD approach can be of substantial benefit. For example, a recent review of prophylaxis of influenza identified the value of timing drug administration relative to onset of symptoms and duration of symptoms ( https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5276059/pdf/10.1186/1741-7015-11-188.pdf ). These data may be used to develop a dosing algorithm for better outcomes. The use of PK/PD principles in the design of vaccines is a novel approach in a disease that is more commonly treated with immunomodulatory agents.
Internet freedom is a shared common value that is under threat, not only in China, Russia, and elsewhere, but also in democracies. It is important to mobilize support in democratic societies for the promotion of the rule of law online, the protection of privacy, the upholding of free expression, and for safeguarding the right to access information.
The final pillar of MAGICS is the creation of a One Digital Economy that benefits all. This may most easily be accomplished by using a rights-respecting approach to internet governance that builds on the principles of transparency, accountability and freedom of expression, and helps ensure a free and open internet. The establishment of a robust multistakeholder mechanism for internet governance that can respond to emerging challenges, such as harmful content and privacy, needs to be implemented and sustained.
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